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クロマチン構成の計算解析を用いたアルツハイマー病変異体の標的遺伝子へのマッピング
JoVE Journal
Genetics
This content is Free Access.
JoVE Journal Genetics
Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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クロマチン構成の計算解析を用いたアルツハイマー病変異体の標的遺伝子へのマッピング

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18,590 Views

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04:41 min

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January 09, 2020

DOI:

10.3791/60428-v

DOI:
10.3791/60428-v

•

04:41 min
January 09, 2020

•

3 Views
, , ,
1Department of Genetics,University of North Carolina, 2Neuroscience Center,University of North Carolina, 3Thurston Arthritis Research Center,University of North Carolina, 4Department of Cell Biology and Physiology,University of North Carolina

Summary

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我々は、三次元クロマチン相互作用を用いてゲノム全体の関連研究(GWAS)によって同定される非コード変異体の機能的影響を同定するプロトコルを提示する。

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Alzheimer’s DiseaseGWASChromatin ConfigurationComputational AnalysisTarget GenesSNPsHi-CGene ExpressionCell-type ExpressionGene Annotation Enrichment

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Cite this Article

Matoba, N., Quiroga, I. Y., Phanstiel, D. H., Won, H. Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration. J. Vis. Exp. (155), e60428, doi:10.3791/60428 (2020).

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