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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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JoVE Journal Genetik
Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

18,590 Views

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04:41 min

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January 09, 2020

DOI:

10.3791/60428-v

DOI:
10.3791/60428-v

•

04:41 min
January 09, 2020

•

3 Views
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1Genetik Bölümü,University of North Carolina, 2Neuroscience Center,University of North Carolina, 3Thurston Arthritis Research Center,University of North Carolina, 4Department of Cell Biology and Physiology,University of North Carolina

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We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

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Alzheimer’s DiseaseGWASChromatin ConfigurationComputational AnalysisTarget GenesSNPsHi-CGene ExpressionCell-type ExpressionGene Annotation Enrichment

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Matoba, N., Quiroga, I. Y., Phanstiel, D. H., Won, H. Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration. J. Vis. Exp. (155), e60428, doi:10.3791/60428 (2020).

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