Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Nana Matoba; Ivana Y. Quiroga; Douglas  H. Phanstiel; Hyejung Won

doi:10.3791/60428

Journal

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Génétique

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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Journal JoVE
Génétique

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Journal JoVE Génétique

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

18,590 Views

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04:41 min

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January 09, 2020

DOI:

10.3791/60428-v

DOI:

10.3791/60428-v

•

04:41 min

January 09, 2020

•

3 Views

Nana Matoba^1,2, Ivana Y. Quiroga³, Douglas H. Phanstiel*^3,4, Hyejung Won*^1,2

¹Department of Genetics,University of North Carolina, ²Neuroscience Center,University of North Carolina, ³Thurston Arthritis Research Center,University of North Carolina, ⁴Department of Cell Biology and Physiology,University of North Carolina

Summary

We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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