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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Genética
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JoVE Revista Genética
Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

18,590 Views

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04:41 min

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January 09, 2020

DOI:

10.3791/60428-v

DOI:
10.3791/60428-v

•

04:41 min
January 09, 2020

•

3 Views
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1Department of Genetics,University of North Carolina, 2Neuroscience Center,University of North Carolina, 3Thurston Arthritis Research Center,University of North Carolina, 4Department of Cell Biology and Physiology,University of North Carolina

Summary

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We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

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Alzheimer’s DiseaseGWASChromatin ConfigurationComputational AnalysisTarget GenesSNPsHi-CGene ExpressionCell-type ExpressionGene Annotation Enrichment

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Cite this Article

Matoba, N., Quiroga, I. Y., Phanstiel, D. H., Won, H. Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration. J. Vis. Exp. (155), e60428, doi:10.3791/60428 (2020).

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