Journal
/
Genetics
/
Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
JoVE Journal
Genetics
This content is Free Access.
JoVE Journal Genetics
Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

English

Automatically Generated

18,590 Views

•

04:41 min

•

January 09, 2020

DOI:

10.3791/60428-v

DOI:
10.3791/60428-v

•

04:41 min
January 09, 2020

•

3 Views
, , ,
1Department of Genetics,University of North Carolina, 2Neuroscience Center,University of North Carolina, 3Thurston Arthritis Research Center,University of North Carolina, 4Department of Cell Biology and Physiology,University of North Carolina

Summary

Automatically generated

We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

Explore More Videos

Alzheimer’s DiseaseGWASChromatin ConfigurationComputational AnalysisTarget GenesSNPsHi-CGene ExpressionCell-type ExpressionGene Annotation Enrichment

Read Article

Cite this Article

Matoba, N., Quiroga, I. Y., Phanstiel, D. H., Won, H. Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration. J. Vis. Exp. (155), e60428, doi:10.3791/60428 (2020).

Download .ris file

Copy

Share Video

.

Copy