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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

DOI:
10.3791/60428-v

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04:41 min

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January 09, 2020

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, , ,
1Department of Genetics,University of North Carolina, 2Neuroscience Center,University of North Carolina, 3Thurston Arthritis Research Center,University of North Carolina, 4Department of Cell Biology and Physiology,University of North Carolina

Chapters

  • 00:05Title
  • 01:00Generation of a Granges Object for Credible SNPs and Positional Mapping
  • 01:53Developmental Expression Trajectories
  • 02:18Cell-type Expression Profiles and Gene Annotation Enrichment Analysis
  • 02:46Results: Determination and Characterization of Putative Target Genes of AD GWS Loci
  • 03:52Conclusion

Summary

자동 번역

자동 번역

We present a protocol to identify functional implications of non-coding variants identified by genome-wide association studies (GWAS) using three-dimensional chromatin interactions.

Tags

Alzheimer’s DiseaseGWASChromatin ConfigurationComputational AnalysisTarget GenesSNPsHi-CGene ExpressionCell-type ExpressionGene Annotation Enrichment

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