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Perturbando a biomecânica endotelial via connexin 43 disrupção estrutural
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Biochemistry
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JoVE Journal Biochemistry
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Perturbando a biomecânica endotelial via connexin 43 disrupção estrutural

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5,381 Views

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09:20 min

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October 04, 2019

DOI:

10.3791/60034-v

DOI:
10.3791/60034-v

•

09:20 min
October 04, 2019

•

1 Views
,
1Department of Mechanical and Aerospace Engineering,University of Central Florida, 2Burnett School of Biomedical Sciences, College of Medicine,University of Central Florida

Summary

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Aqui, apresentamos um protocolo baseado em mecânica para interromper a junção de Gap conexina 43 e medir o impacto subsequente que isso tem sobre a biomecânica endotelial através da observação de tracções e tensões intercelulares.

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Islam, M. M., Steward, Jr., R. L. Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption. J. Vis. Exp. (152), e60034, doi:10.3791/60034 (2019).

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