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コネクシン43構造破壊による内皮バイオメカニクスの摂動

JoVE Journal
Biochemistry

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JoVE Journal Biochemistry

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

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コネクシン43構造破壊による内皮バイオメカニクスの摂動

5,381 Views

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09:20 min

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October 04, 2019

DOI:

10.3791/60034-v

DOI:

10.3791/60034-v

•

09:20 min

October 04, 2019

•

1 Views

Md. Mydul Islam¹, Robert L. Steward, Jr.^1,2

¹Department of Mechanical and Aerospace Engineering,University of Central Florida, ²Burnett School of Biomedical Sciences, College of Medicine,University of Central Florida

Summary

ここでは、ギャップ接合コネクシン43を破壊する力学ベースのプロトコルを提示し、トラクションと細胞間応力の観察を通じて内皮バイオメカニクスに及ぼすその後の影響を測定する。

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