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Lesão Neuronal Direcionada para a Desconexão Não Invasiva do Circuito Cerebral
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10:58 min
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September 27, 2020
DOI:
1Department of Neuroscience,University of Virginia, 2Department of Radiology,Stanford University, 3Department of Neurology,University of Virginia, 4Global Internship Program,Focused Ultrasound Foundation, 5Department of Medicine,University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery,University of Virginia, 8Center for Brain, Immunology, and Glia,University of Virginia
Summary
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O objetivo do protocolo é fornecer um método para produzir lesões neuronais não invasivas no cérebro. O método utiliza o Ultrassom Focalizado guiado por Ressonância Magnética (MRgFUS) para abrir a Barreira Cerebral sanguínea de forma transitória e focal, a fim de fornecer uma neurotoxina circulante para o parenchyma cerebral.
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Wang, W., Zhang, Y., Anzivino, M. J., Bertram, E. H., Woznak, J., Klibanov, A., Dumont, E., Wintermark, M., Lee, K. S. Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry. J. Vis. Exp. (163), e61271, doi:10.3791/61271 (2020).
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