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JoVE Journal Neuroscience
Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
 

Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

Article DOI: 10.3791/61271-v • 10:58 min • September 27th, 2020
September 27th, 2020 •
*1, *2, 1, 3, 1,4, 5, 6, *2, *1,7,8
1Department of Neuroscience, University of Virginia, 2Department of Radiology, Stanford University, 3Department of Neurology, University of Virginia, 4Global Internship Program, Focused Ultrasound Foundation, 5Department of Medicine, University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery, University of Virginia, 8Center for Brain, Immunology, and Glia, University of Virginia
* These authors contributed equally

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The goal of the protocol is to provide a method for producing non-invasive neuronal lesions in the brain. The method utilizes Magnetic Resonance-guided Focused Ultrasound (MRgFUS) to open the Blood Brain Barrier in a transient and focal manner, in order to deliver a circulating neurotoxin to the brain parenchyma.

Tags

Targeted Neuronal Injury Non-invasive Disconnection Brain Circuitry Surgical Intervention Invasive Procedures Surgical Injury Noninvasive Technique Neuronal Lesions Precise Interest Cerebral Noninvasive Guided Surgery Ping Method Blood-brain Barrier Opening Neurotoxin Systemically Brain Parenchyma Animal Preparation Ping Procedure Post-mortem Cellular Analyses Anesthesia
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