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脑回路非侵入性断开的靶向神经元损伤
JoVE Journal
Neuroscience
Author Produced
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JoVE Journal Neuroscience
Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
DOI:

10:58 min

September 27, 2020

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Chapters

  • 00:00Introduction
  • 01:36Animal Preparation
  • 02:44PING Procedure
  • 05:55MRI/FUS Control Room
  • 06:35Targeting of FUS
  • 07:07Administration of Microbubble, FUS, and Contrast Age
  • 07:47Infusion of Quinolinic Acid
  • 08:15Results: Imaging and Microscopy
  • 10:03Conclusions for PING Method

Summary

Automatic Translation

该协议的目标是提供一种在大脑中产生非侵入性神经元病变的方法。该方法利用磁共振引导聚焦超声(MRgFUS)以瞬态和焦焦的方式打开血脑屏障,为脑帕伦奇瘤提供循环神经毒素。

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