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Lesioni neuronali mirate per la disconnessione non invasiva dei circuiti cerebrali
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10:58 min
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September 27, 2020
DOI:
1Department of Neuroscience,University of Virginia, 2Department of Radiology,Stanford University, 3Department of Neurology,University of Virginia, 4Global Internship Program,Focused Ultrasound Foundation, 5Department of Medicine,University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery,University of Virginia, 8Center for Brain, Immunology, and Glia,University of Virginia
Summary
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L'obiettivo del protocollo è quello di fornire un metodo per produrre lesioni neuronali non invasive nel cervello. Il metodo utilizza l'ecografia focalizzata a risonanza magnetica (MRgFUS) per aprire la barriera del cervello del sangue in modo transitorio e focale, al fine di fornire una neurotossina circolante al parenchyma cerebrale.
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Wang, W., Zhang, Y., Anzivino, M. J., Bertram, E. H., Woznak, J., Klibanov, A., Dumont, E., Wintermark, M., Lee, K. S. Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry. J. Vis. Exp. (163), e61271, doi:10.3791/61271 (2020).
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