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Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries
JoVE Journal
Neuroscience
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JoVE Journal Neuroscience
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

English

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6,884 Views

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08:21 min

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April 01, 2019

DOI:

10.3791/58792-v

DOI:
10.3791/58792-v

•

08:21 min
April 01, 2019

•

3 Views
, , , , ,
1Charles R. Allen Research Laboratories, Department of Anesthesiology,University of Texas Medical Branch, 2The Moody Project for Translational Traumatic Brain Injury Research,University of Texas Medical Branch

Summary

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Here, we present a protocol to describe methods for ex vivo vascular reactivity determination following a primary blast traumatic brain injury (bTBI) using isolated, pressurized, rodent middle cerebral arterial (MCA) segments. bTBI induction is accomplished using a shock tube, also known as an Advanced Blast Simulator (ABS) device.

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Rodriguez, U. A., Zeng, Y., Parsley, M. A., Hawkins, B. E., Prough, D. S., DeWitt, D. S. Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries. J. Vis. Exp. (146), e58792, doi:10.3791/58792 (2019).

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