需要订阅 JoVE 才能查看此. 登录或开始免费试用。
Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
4,994 Views
•
10:58 min
•
September 27, 2020
DOI:
1Department of Neuroscience,University of Virginia, 2Department of Radiology,Stanford University, 3Department of Neurology,University of Virginia, 4Global Internship Program,Focused Ultrasound Foundation, 5Department of Medicine,University of Virginia, 6Image Guided Therapy, 7Department of Neurosurgery,University of Virginia, 8Center for Brain, Immunology, and Glia,University of Virginia
Summary
Automatically generated
The goal of the protocol is to provide a method for producing non-invasive neuronal lesions in the brain. The method utilizes Magnetic Resonance-guided Focused Ultrasound (MRgFUS) to open the Blood Brain Barrier in a transient and focal manner, in order to deliver a circulating neurotoxin to the brain parenchyma.
Read Article
Cite this Article
Wang, W., Zhang, Y., Anzivino, M. J., Bertram, E. H., Woznak, J., Klibanov, A., Dumont, E., Wintermark, M., Lee, K. S. Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry. J. Vis. Exp. (163), e61271, doi:10.3791/61271 (2020).
Copy