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Análisis de metilación de ADN completo usando un método de captura de dominio de unión a metil-CpG en pacientes con leucemia linfocítica crónica
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Genetics
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JoVE Journal Genetics
Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Análisis de metilación de ADN completo usando un método de captura de dominio de unión a metil-CpG en pacientes con leucemia linfocítica crónica

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9,685 Views

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13:21 min

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June 16, 2017

DOI:

10.3791/55773-v

DOI:
10.3791/55773-v

•

13:21 min
June 16, 2017

•

4 Views
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1Department of Medical Genetics, Institute of Biomedicine,Gothenburg University, 2Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine,Gothenburg University

Summary

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Este trabajo describe un optimizado metil-CpG vinculante dominio de secuenciación de protocolo y una tubería computacional para identificar diferencial metilado CpG-ricos en regiones crónicas linfocítica leucemia (CLL) pacientes.

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Subhash, S., Kanduri, M. Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients. J. Vis. Exp. (124), e55773, doi:10.3791/55773 (2017).

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