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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Chapters
- 00:05Title
- 00:45Tumor Cell Implantation
- 02:43[18F]FDG-PET/CT Imaging
- 04:12Analysis of [18F]FDG-PET/CT Scans
- 06:08Results: Malignant Pleural Mesothelioma Monitoring with [18F]FDG-PET/CT Imaging
- 06:59Conclusion
This article describes the generation of an orthotopic mouse model of human pleural mesothelioma by implantation of H2052/484 mesothelioma cells into the pleural cavity of immunocompromised athymic mice. The longitudinal monitoring of the development of intrapleural tumors was assessed by non-invasive multimodal [18F]-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography imaging.
