Journal
/
Developmental Biology
/
Realizando xenoenxertos de músculo esquelético humano em camundongos imunodeficientes
JoVE Journal
Developmental Biology
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Developmental Biology
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Realizando xenoenxertos de músculo esquelético humano em camundongos imunodeficientes

português

Automatically Generated

9,446 Views

•

07:48 min

•

September 16, 2019

DOI:

10.3791/59966-v

DOI:
10.3791/59966-v

•

07:48 min
September 16, 2019

•

10 Views
, , ,
1Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, 2Department of Neurology,Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience,Johns Hopkins University School of Medicine

Summary

Automatically generated

Doenças humanas complexas podem ser desafiadoras para modelar em sistemas de modelos laboratoriais tradicionais. Aqui, nós descrevemos uma aproximação cirúrgica para modelar a doença do músculo humano com a transplantação de biópsias humanas do músculo esqueletal em ratos immunodeficientes.

Explore More Videos

Human Skeletal Muscle XenograftsImmunodeficient MiceMuscle Disease ModelingPreclinical Therapeutic TestingHuman Muscle Cell BiologyRare Or Acquired Muscle DiseasesMuscle BiopsyNOD-Rag-gamma MouseTibialis AnteriorExtensor Digitorum LongusPeroneus LongusSurgical Procedure

Read Article

Cite this Article

Britson, K. A., Black, A. D., Wagner, K. R., Lloyd, T. E. Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice. J. Vis. Exp. (151), e59966, doi:10.3791/59966 (2019).

Download .ris file

Copy

Share Video

.

Copy