Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Kyla A. Britson; Aaron  D. Black; Kathryn  R. Wagner; Thomas  E. Lloyd

doi:10.3791/59966

Journal

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Biologie du développement

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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Journal JoVE
Biologie du développement

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Journal JoVE Biologie du développement

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

9,465 Views

•

07:48 min

•

September 16, 2019

DOI:

10.3791/59966-v

DOI:

10.3791/59966-v

•

07:48 min

September 16, 2019

•

10 Views

Kyla A. Britson^1,2, Aaron D. Black^2,3, Kathryn R. Wagner^1,2,3,4, Thomas E. Lloyd^1,2,4

¹Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, ²Department of Neurology,Johns Hopkins University School of Medicine, ³Kennedy Krieger Institute, ⁴Department of Neuroscience,Johns Hopkins University School of Medicine

Summary

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

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Human Skeletal Muscle Xenografts Immunodeficient Mice Muscle Disease Modeling Preclinical Therapeutic Testing Human Muscle Cell Biology Rare Or Acquired Muscle Diseases Muscle Biopsy NOD-Rag-gamma Mouse Tibialis Anterior Extensor Digitorum Longus Peroneus Longus Surgical Procedure

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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

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