Dergi
/
Gelişim Biyolojisi
/
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
JoVE Journal
Gelişim Biyolojisi
Bu içeriği görüntülemek için JoVE aboneliği gereklidir.  Oturum açın veya ücretsiz deneme sürümünü başlatın.
JoVE Journal Gelişim Biyolojisi
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

9,462 Views

•

07:48 min

•

September 16, 2019

DOI:

10.3791/59966-v

DOI:
10.3791/59966-v

•

07:48 min
September 16, 2019

•

10 Views
, , ,
1Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, 2Department of Neurology,Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Nörobilim Bölümü,Johns Hopkins University School of Medicine

Özet

Automatically generated

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

Explore More Videos

Human Skeletal Muscle XenograftsImmunodeficient MiceMuscle Disease ModelingPreclinical Therapeutic TestingHuman Muscle Cell BiologyRare Or Acquired Muscle DiseasesMuscle BiopsyNOD-Rag-gamma MouseTibialis AnteriorExtensor Digitorum LongusPeroneus LongusSurgical Procedure

Read Article

Cite this Article

Britson, K. A., Black, A. D., Wagner, K. R., Lloyd, T. E. Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice. J. Vis. Exp. (151), e59966, doi:10.3791/59966 (2019).

Download .ris file

Copy

Share Video

.

Copy