Journal
/
Developmental Biology
/
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
JoVE Journal
Developmental Biology
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Developmental Biology
Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

English

Automatically Generated

9,465 Views

•

07:48 min

•

September 16, 2019

DOI:

10.3791/59966-v

DOI:
10.3791/59966-v

•

07:48 min
September 16, 2019

•

10 Views
, , ,
1Graduate Program in Cellular and Molecular Medicine,Johns Hopkins University School of Medicine, 2Department of Neurology,Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience,Johns Hopkins University School of Medicine

Summary

Automatically generated

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

Explore More Videos

Human Skeletal Muscle XenograftsImmunodeficient MiceMuscle Disease ModelingPreclinical Therapeutic TestingHuman Muscle Cell BiologyRare Or Acquired Muscle DiseasesMuscle BiopsyNOD-Rag-gamma MouseTibialis AnteriorExtensor Digitorum LongusPeroneus LongusSurgical Procedure

Read Article

Cite this Article

Britson, K. A., Black, A. D., Wagner, K. R., Lloyd, T. E. Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice. J. Vis. Exp. (151), e59966, doi:10.3791/59966 (2019).

Download .ris file

Copy

Share Video

.

Copy