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SPLINTER kullanarak Pooled Sıralama gelen Nadir Genomik Variantların Algılama
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Biology
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JoVE Journal Biology
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
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SPLINTER kullanarak Pooled Sıralama gelen Nadir Genomik Variantların Algılama

Türkçe

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14,862 Views

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14:06 min

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June 23, 2012

DOI:

10.3791/3943-v

DOI:
10.3791/3943-v

•

14:06 min
June 23, 2012

•

3 Views
, , , ,
1Center for Genome Sciences and Systems Biology, Department of Genetics,Washington University School of Medicine, 2Department of Internal Medicine,Washington University School of Medicine, 3Department of Pediatrics,Washington University School of Medicine

Summary

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Pooled DNA dizi büyük kohortlarında karmaşık fenotipleri ile ilişkili nadir türevlerini algılamak için hızlı ve maliyet-etkin bir stratejidir. Burada SPLINTER'da yazılım paketi kullanarak 32 kanser ilişkili genlerin havuzlu, yeni nesil dizileme sayısal analiz açıklanmaktadır. Bu yöntem, ölçeklenebilir ve menfaat fenotipi için geçerlidir.

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Cite this Article

Vallania, F., Ramos, E., Cresci, S., Mitra, R. D., Druley, T. E. Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER. J. Vis. Exp. (64), e3943, doi:10.3791/3943 (2012).

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