Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Madison I. Moss; Mariela Pauli; Joshua M. Moreau; Jarish N. Cohen; Michael D. Rosenblum; Margaret M. Lowe

doi:10.3791/64040

Journal

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면역학 및 감염병학

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异种移植皮肤模型在体内操纵人类免疫反应

JoVE 신문
면역학 및 감염병학
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JoVE 신문 면역학 및 감염병학

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

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异种移植皮肤模型在体内操纵人类免疫反应

DOI:

10.3791/64040-v

•

08:23 min

•

June 29, 2022

•

Madison I. Moss, Mariela Pauli, Joshua M. Moreau, Jarish N. Cohen, Michael D. Rosenblum, Margaret M. Lowe

¹Department of Dermatology,UCSF, ²TRex Bio

Chapters

00:04Introduction
00:59Processing of Donor Human Skin Sample
02:15Pre-Surgery Conditioning and Preparation
03:42Transplantation Procedure
06:09Results: Analysis of the Xenografts
07:35Conclusion

Summary

자동 번역

本协议描述了如何将人体皮肤移植到非肥胖糖尿病（NOD）-scid白细胞介素-2γ链受体（NSG）小鼠上。报告中详细介绍了移植用人体皮肤的制备、移植用小鼠的准备、裂层人体皮肤的移植以及移植后的恢复程序。

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