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Xenograft Skin Model to Manipulate Human Immune Responses In Vivo
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June 29, 2022
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The present protocol describes how to graft human skin onto non-obese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) mice. A detailed description of the preparation of human skin for transplant, preparation of mice for transplant, transplantation of split-thickness human skin, and post-transplantation recovery procedure are included in the report.
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Moss, M. I., Pauli, M., Moreau, J. M., Cohen, J. N., Rosenblum, M. D., Lowe, M. M. Xenograft Skin Model to Manipulate Human Immune Responses In Vivo. J. Vis. Exp. (184), e64040, doi:10.3791/64040 (2022).
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