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利用染色质配置的计算分析，将阿尔茨海默氏病变异体映射到其目标基因

Journal JoVE
Génétique

This content is Free Access.

Journal JoVE Génétique

Mapping Alzheimer’s Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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利用染色质配置的计算分析，将阿尔茨海默氏病变异体映射到其目标基因

18,553 Views

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04:41 min

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January 09, 2020

DOI:

10.3791/60428-v

DOI:

10.3791/60428-v

•

04:41 min

January 09, 2020

•

3 Views

Nana Matoba^1,2, Ivana Y. Quiroga³, Douglas H. Phanstiel*^3,4, Hyejung Won*^1,2

¹Department of Genetics,University of North Carolina, ²Neuroscience Center,University of North Carolina, ³Thurston Arthritis Research Center,University of North Carolina, ⁴Department of Cell Biology and Physiology,University of North Carolina

Summary

我们提出了一个协议，用于识别使用三维染色质相互作用的全基因组关联研究（GWAS）识别的非编码变异的功能影响。

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