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人类免疫缺陷小鼠模型中的慢性、急性和再激活HIV感染
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Immunology and Infection
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JoVE Journal Immunology and Infection
Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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人类免疫缺陷小鼠模型中的慢性、急性和再激活HIV感染

DOI:
10.3791/60315-v

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09:54 min

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December 03, 2019

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, , , , ,
1Institute of Human Virology, School of Medicine,University of Maryland, 2Grupo Inmunovirología, Facultad de Medicina,Universidad de Antioquia

Chapters

  • 00:04Title
  • 00:45Human CD34+ Hematopoietic Stem Cells (HSC) Engraftment of Newborn Mice
  • 04:18Human Peripheral Blood Mononuclear Cell (PBMC) Engraftment of Juvenile Mice
  • 07:29Results: Representative Changes of Viral Load and CD4:CD8 Ratio in huNS -chainnull Mice after HIV Infection and after Anti-retroviral Therapy Introduction
  • 08:41Conclusion

Summary

Automatic Translation

Automatic Translation

本文介绍了三种研究人类小鼠HIV感染动态的实验方法。前者允许研究慢性感染事件，而后者允许研究原发感染或病毒重新激活后的急性事件。

Tags

Chronic HIV InfectionAcute HIV InfectionReactivated HIV InfectionHumanized Immunodeficient Mouse ModelsNSG Humanized MiceCD34+ Human Stem CellsHepatic InjectionHIV Pre-clinical Studies

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