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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
JoVE Journal
Kanser Araştırmaları
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JoVE Journal Kanser Araştırmaları
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

DOI:
10.3791/60431-v

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08:00 min

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October 11, 2019

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, ,
1Lyrid LLC, 2Independent consultant, 3Information Sciences Institute,University of Southern California

Bölümler

  • 00:04Başlık
  • 00:41Exploring Factors Containing a Gene of Interest
  • 03:06Filtering and Interpreting CorEx Factors and Finding Commonalities and Differences of Gene Expression Variation Across Tumor Types
  • 05:49Results: Representative Tumor Gene Expression Factor Analysis
  • 07:31Conclusion

Özet

Otomatik Çeviri

Otomatik Çeviri

We introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.

Etiketler

CorExplorerTumor Gene ExpressionInformation MaximizationLatent FactorsCancer BiologyTCGALung CancerRNA SequencingFactor GraphGene ExpressionBiological DiscoveryGene-factor Associations

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