ジャーナル
/
がん研究
/
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
JoVE Journal
がん研究
This content is Free Access.
JoVE Journal がん研究
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

DOI:
10.3791/60431-v

•

08:00 min

•

October 11, 2019

•

, ,
1Lyrid LLC, 2Independent consultant, 3Information Sciences Institute,University of Southern California

章

  • 00:04標題
  • 00:41Exploring Factors Containing a Gene of Interest
  • 03:06Filtering and Interpreting CorEx Factors and Finding Commonalities and Differences of Gene Expression Variation Across Tumor Types
  • 05:49Results: Representative Tumor Gene Expression Factor Analysis
  • 07:31Conclusion

概要

自動翻訳

自動翻訳

We introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.

タグ

CorExplorerTumor Gene ExpressionInformation MaximizationLatent FactorsCancer BiologyTCGALung CancerRNA SequencingFactor GraphGene ExpressionBiological DiscoveryGene-factor Associations

Article

Embed

プレイリスト追加

Usage Statistics

関連ビデオ

The Drosophila Imaginal Disc Tumor Model: Visualization and Quantification of Gene Expression and Tumor Invasiveness Using Genetic Mosaics

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model

Conditional Knockdown of Gene Expression in Cancer Cell Lines to Study the Recruitment of Monocytes/Macrophages to the Tumor Microenvironment

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro

Digital Polymerase Chain Reaction Assay for the Genetic Variation in a Sporadic Familial Adenomatous Polyposis Patient Using the Chip-in-a-tube Format

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Read Article