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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
JoVE 杂志
癌症研究
This content is Free Access.
JoVE 杂志 癌症研究
Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
DOI:

08:00 min

October 11, 2019

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Chapters

  • 00:04Title
  • 00:41Exploring Factors Containing a Gene of Interest
  • 03:06Filtering and Interpreting CorEx Factors and Finding Commonalities and Differences of Gene Expression Variation Across Tumor Types
  • 05:49Results: Representative Tumor Gene Expression Factor Analysis
  • 07:31Conclusion

Summary

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We introduce the CorExplorer web portal, an resource for exploration of tumor RNA sequencing factors found by the machine learning algorithm CorEx (Correlation Explanation), and show how factors can be analyzed relative to survival, database annotations, protein-protein interactions, and one another to gain insight into tumor biology and therapeutic interventions.

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