BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABA<sub>A</sub> Receptor Presentation in the Rodent Brain

Akiko Sumitomo; Runhao Zhou; Thomas Prevot; Etienne Sibille; Toshifumi Tomoda

doi:10.3791/65063

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BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABA_A Receptor Presentation in the Rodent Brain

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Neurociência

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JoVE Journal Neurociência

BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABA_A Receptor Presentation in the Rodent Brain

872 Views

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05:17 min

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May 26, 2023

DOI:

10.3791/65063-v

DOI:

10.3791/65063-v

•

05:17 min

May 26, 2023

•

5 Views

Akiko Sumitomo¹, Runhao Zhou^1,2, Thomas Prevot^1,3, Etienne Sibille^1,2,3, Toshifumi Tomoda^1,3

¹Centre for Addiction and Mental Health (CAMH),Campbell Family Mental Health Research Institute, ²Department of Pharmacology and Toxicology,University of Toronto, ³Department of Psychiatry,University of Toronto

Summary

The BS3 chemical crosslinking assay reveals reduced cell surface GABA_A receptor expression in mouse brains under chronic psychosocial stress conditions.

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BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABAA Receptor Presentation in the Rodent Brain

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BS3 Chemical Crosslinking Assay: Evaluating the Effect of Chronic Stress on Cell Surface GABA_A Receptor Presentation in the Rodent Brain