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JoVE Journal Behavior
Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
 

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Article DOI: 10.3791/61743-v • 07:38 min • May 27th, 2021
May 27th, 2021 •
*1, *1, 1
1The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center, Bar-Ilan University
* These authors contributed equally

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요약
Automatic Translation

We present protocols for generating acute and chronic experimental models of tic expression in freely behaving rats. The models are based on striatal cannula implantation and subsequent GABAA antagonist application. The acute model uses transient injections whereas the chronic model utilizes prolonged infusions via a subcutaneous implanted mini-osmotic pump.

Tags

Experimental Models Motor Tic Expression Rats Acute Model Chronic Model Tic Disorders Tourette Syndrome Custom-made Device Preparation Implantation Surgery Implant Cannula Flexible Polymer Microbore Tube Injection Cannula Surgery Rat's Brain Dental Cement
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