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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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May 27, 2021
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We present protocols for generating acute and chronic experimental models of tic expression in freely behaving rats. The models are based on striatal cannula implantation and subsequent GABAA antagonist application. The acute model uses transient injections whereas the chronic model utilizes prolonged infusions via a subcutaneous implanted mini-osmotic pump.
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Vinner, E., Belelovsky, K., Bar-Gad, I. Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats. J. Vis. Exp. (171), e61743, doi:10.3791/61743 (2021).
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