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Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats
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Behavior
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JoVE Journal Behavior
Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats

English

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6,785 Views

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07:38 min

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May 27, 2021

DOI:

10.3791/61743-v

DOI:
10.3791/61743-v

•

07:38 min
May 27, 2021

•

25 Views
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1The Leslie & Susan Goldschmied (Gonda) Multidisciplinary Brain Research Center,Bar-Ilan University

Summary

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We present protocols for generating acute and chronic experimental models of tic expression in freely behaving rats. The models are based on striatal cannula implantation and subsequent GABAA antagonist application. The acute model uses transient injections whereas the chronic model utilizes prolonged infusions via a subcutaneous implanted mini-osmotic pump.

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Cite this Article

Vinner, E., Belelovsky, K., Bar-Gad, I. Generating Acute and Chronic Experimental Models of Motor Tic Expression in Rats. J. Vis. Exp. (171), e61743, doi:10.3791/61743 (2021).

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