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一种利用19f 核磁共振光谱测定脂质性 (日志 p) 的新方法
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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
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一种利用19f 核磁共振光谱测定脂质性 (日志 p) 的新方法

13,903 Views

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09:32 min

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January 30, 2019

DOI:

10.3791/58567-v

DOI:
10.3791/58567-v

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09:32 min
January 30, 2019

•

14 Views
, , , , ,
1화학,University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit,AstraZeneca

Summary

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利用19f 核磁共振光谱法, 建立了一种新的、直接的振动瓶法的变化, 用于对氟化化合物进行准确的亲脂性测量。

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Cite this Article

Wang, Z., Jeffries, B. F., Felstead, H. R., Wells, N. J., Chiarparin, E., Linclau, B. A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy. J. Vis. Exp. (143), e58567, doi:10.3791/58567 (2019).

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