A New Straightforward Method for Lipophilicity (log<em>P</em>) Measurement using <sup>19</sup>F NMR Spectroscopy

Zhong Wang; Benjamin F. Jeffries; Hannah R. Felstead; Neil J. Wells; Elisabetta Chiarparin; Bruno Linclau

doi:10.3791/58567

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Chimica

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A New Straightforward Method for Lipophilicity (logP) Measurement using ¹⁹F NMR Spectroscopy

JoVE Journal
Chimica

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JoVE Journal Chimica

A New Straightforward Method for Lipophilicity (logP) Measurement using ¹⁹F NMR Spectroscopy

13,905 Views

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09:32 min

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January 30, 2019

DOI:

10.3791/58567-v

DOI:

10.3791/58567-v

•

09:32 min

January 30, 2019

•

14 Views

Zhong Wang¹, Benjamin F. Jeffries¹, Hannah R. Felstead¹, Neil J. Wells¹, Elisabetta Chiarparin², Bruno Linclau¹

¹Chimica,University of Southampton, ²Medicinal Chemistry, Oncology, IMED Biotech Unit,AstraZeneca

Summary

A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by ¹⁹F NMR spectroscopy.

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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

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A New Straightforward Method for Lipophilicity (logP) Measurement using ¹⁹F NMR Spectroscopy