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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
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A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy

13,905 Views

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09:32 min

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January 30, 2019

DOI:

10.3791/58567-v

DOI:
10.3791/58567-v

•

09:32 min
January 30, 2019

•

14 Views
, , , , ,
1화학,University of Southampton, 2Medicinal Chemistry, Oncology, IMED Biotech Unit,AstraZeneca

Summary

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A novel and straightforward variation of the shake-flask method was developed for accurate lipophilicity measurement of fluorinated compounds by 19F NMR spectroscopy.

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Wang, Z., Jeffries, B. F., Felstead, H. R., Wells, N. J., Chiarparin, E., Linclau, B. A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy. J. Vis. Exp. (143), e58567, doi:10.3791/58567 (2019).

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