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Canalostomy As a Surgical Approach to Local Drug Delivery into the Inner Ears of Adult and Neonatal Mice
Chapters
- 00:05Title
- 00:56Device Preparation
- 02:31Canalostomy in Adult Mice
- 05:58Canalostomy in Neonatal Mice
- 06:48Results: Drug Delivery by Canalostomy Resulted in Widespread Distribution of the Reagent Throughout the Cochlea and Vestibular End-organs
- 08:13Conclusion
Here we describe canalostomy procedure which allows local drug delivery into the inner ears of adult and neonatal mice through the semicircular canal with minimum damage to hearing and vestibular function. This method can be used to inoculate viral vectors, pharmaceuticals, and small molecules into the mouse inner ear.
