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实验脱髓鞘和小鼠脊髓髓鞘再生由溶血卵磷脂的焦点注射
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신경과학
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JoVE 신문 신경과학
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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实验脱髓鞘和小鼠脊髓髓鞘再生由溶血卵磷脂的焦点注射

26,502 Views

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08:57 min

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March 26, 2015

DOI:

10.3791/52679-v

DOI:
10.3791/52679-v

•

08:57 min
March 26, 2015

•

19 Views
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1Department of Clinical Neurosciences,Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology,Hotchkiss Brain Institute at University of Calgary

Summary

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Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

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Cite this Article

Keough, M. B., Jensen, S. K., Yong, V. W. Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin. J. Vis. Exp. (97), e52679, doi:10.3791/52679 (2015).

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