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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
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March 26, 2015
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Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.
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Keough, M. B., Jensen, S. K., Yong, V. W. Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin. J. Vis. Exp. (97), e52679, doi:10.3791/52679 (2015).
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