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JoVE Journal Neuroscience
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
 

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Article DOI: 10.3791/52679-v • 08:57 min • March 26th, 2015
March 26th, 2015 •
1, 1, 1,2
1Department of Clinical Neurosciences, Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology, Hotchkiss Brain Institute at University of Calgary

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Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

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Keywords: Experimental Demyelination Remyelination Murine Spinal Cord Lysolecithin Multiple Sclerosis Oligodendrocyte Precursor Cells Animal Model Central Nervous System Spinal Cord White Matter Remyelination-promoting Therapeutics
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