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神经科学
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Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
JoVE 杂志
神经科学
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JoVE 杂志 神经科学
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

26,549 Views

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08:57 min

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March 26, 2015

DOI:

10.3791/52679-v

DOI:
10.3791/52679-v

•

08:57 min
March 26, 2015

•

19 Views
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1Department of Clinical Neurosciences,Hotchkiss Brain Institute at University of Calgary, 2Department of Oncology,Hotchkiss Brain Institute at University of Calgary

Summary

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Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.

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Keough, M. B., Jensen, S. K., Yong, V. W. Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin. J. Vis. Exp. (97), e52679, doi:10.3791/52679 (2015).

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