Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Gemma Llovera; Stefan Roth; Nikolaus Plesnila; Roland Veltkamp; Arthur Liesz

doi:10.3791/51729

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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

36,006 Views

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08:14 min

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July 31, 2014

DOI:

10.3791/51729-v

DOI:

10.3791/51729-v

•

08:14 min

July 31, 2014

•

33 Views

Gemma Llovera*^1,2, Stefan Roth*^1,2, Nikolaus Plesnila^1,2, Roland Veltkamp^3,4, Arthur Liesz^1,2

¹Institute for Stroke and Dementia Research,University Hospital Munich, ²Munich Cluster for Systems Neurology (SyNergy), ³Department of Neurology,University Heidelberg, ⁴Imperial College,Charing Cross Hospital

Summary

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

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Stroke Mouse Model Middle Cerebral Artery Coagulation Infarct Permanent Occlusion Cortex Reproducibility Low Mortality Pathophysiology Inflammation Angiogenesis Plasticity Regeneration Therapeutic Strategies

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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

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