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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
JoVE 杂志
医学
This content is Free Access.
JoVE 杂志 医学
Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

DOI:
10.3791/51729-v

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08:14 min

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July 31, 2014

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, , , ,
1Institute for Stroke and Dementia Research,University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology,University Heidelberg, 4Imperial College,Charing Cross Hospital

Chapters

  • 00:05Title
  • 01:38Preparations
  • 02:32The Distal MCAO Model
  • 04:52The Cylinder Test
  • 05:45Measuring the Infarction
  • 06:31Mortality, Behavioral Change, and Infarct Characterization
  • 07:30Conclusion

Summary

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Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

Tags

Keywords: StrokeMouse ModelMiddle Cerebral ArteryCoagulationInfarctPermanent OcclusionCortexReproducibilityLow MortalityPathophysiologyInflammationAngiogenesisPlasticityRegenerationTherapeutic Strategies

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