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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery
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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

36,015 Views

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08:14 min

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July 31, 2014

DOI:

10.3791/51729-v

DOI:
10.3791/51729-v

•

08:14 min
July 31, 2014

•

33 Views
, , , ,
1Institute for Stroke and Dementia Research,University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology,University Heidelberg, 4Imperial College,Charing Cross Hospital

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Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

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Cite this Article

Llovera, G., Roth, S., Plesnila, N., Veltkamp, R., Liesz, A. Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery. J. Vis. Exp. (89), e51729, doi:10.3791/51729 (2014).

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