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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells
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January 03, 2012
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An in vitro model for cerebral malaria sequestration is described1. Plasmodium falciparum infected red blood cells are selected for binding to immortalized human brain microvascular endothelial cells. The selected parasites show a distinct phenotype. The selection process can be applied using various P. falciparum strains and endothelial cell lines.
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Claessens, A., Rowe, J. A. Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells. J. Vis. Exp. (59), e3122, doi:10.3791/3122 (2012).
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