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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
JoVE Journal
Entwicklungsbiologie
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JoVE Journal Entwicklungsbiologie
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

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11:42 min

April 07, 2017

DOI:

11:42 min
April 07, 2017

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Summary

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We present here a cell culture method for inducing mesenchymal-epithelial transitions (MET) in sarcoma cells based on combined ectopic expression of microRNA-200 family members and grainyhead-like 2 (GRHL2). This method is suitable for better understanding the biological impact of phenotypic plasticity on cancer aggressiveness and treatments.

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