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Biochemistry
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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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Kimeraları Hedefleyen Proteoliz Tarafından İndüklenen Üçlü Kompleks Oluşumunun Değerlendirilmesi için Biyofiziksel Testlerin Geliştirilmesi ve Uygulanması (PROTACS)
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Biochemistry
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JoVE Journal Biochemistry
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
Please note that all translations are automatically generated. Click here for the English version.

Kimeraları Hedefleyen Proteoliz Tarafından İndüklenen Üçlü Kompleks Oluşumunun Değerlendirilmesi için Biyofiziksel Testlerin Geliştirilmesi ve Uygulanması (PROTACS)

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01:09 min

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January 12, 2024

DOI:

10.3791/65718-v

DOI:
10.3791/65718-v

•

01:09 min
January 12, 2024

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41 Views
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1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

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Biophysical AssaysTernary Complex FormationProteolysis Targeting Chimeras (PROTACs)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)Isothermal Titration Calorimetry (ITC)Brd4BD2VHLPPM1DCereblon (CRBN)KineticsThermodynamicsCooperativityHook Effect

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Jiang, W., Soutter, H. The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS). J. Vis. Exp. (203), e65718, doi:10.3791/65718 (2024).

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