Journal
/
Biochemistry
/
Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
/
Разработка и применение биофизических анализов для оценки образования тройных комплексов, индуцированных протеолизом, нацеленным на химеры (PROTACS)
JoVE Journal
Biochemistry
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Biochemistry
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
Please note that all translations are automatically generated. Click here for the English version.

Разработка и применение биофизических анализов для оценки образования тройных комплексов, индуцированных протеолизом, нацеленным на химеры (PROTACS)

русский

Automatically Generated

1,835 Views

•

01:09 min

•

January 12, 2024

DOI:

10.3791/65718-v

DOI:
10.3791/65718-v

•

01:09 min
January 12, 2024

•

41 Views
,
1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Explore More Videos

Biophysical AssaysTernary Complex FormationProteolysis Targeting Chimeras (PROTACs)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)Isothermal Titration Calorimetry (ITC)Brd4BD2VHLPPM1DCereblon (CRBN)KineticsThermodynamicsCooperativityHook Effect

Read Article

Cite this Article

Jiang, W., Soutter, H. The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS). J. Vis. Exp. (203), e65718, doi:10.3791/65718 (2024).

Download .ris file

Copy

Share Video

.

Copy