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Biochemistry
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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays
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キメラを標的としたタンパク質分解による三元複合体形成評価のための生物物理学的アッセイの開発と応用(PROTACS)
JoVE Journal
Biochemistry
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JoVE Journal Biochemistry
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)
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キメラを標的としたタンパク質分解による三元複合体形成評価のための生物物理学的アッセイの開発と応用(PROTACS)

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1,835 Views

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01:09 min

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January 12, 2024

DOI:

10.3791/65718-v

DOI:
10.3791/65718-v

•

01:09 min
January 12, 2024

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41 Views
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1Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

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Biophysical AssaysTernary Complex FormationProteolysis Targeting Chimeras (PROTACs)Surface Plasmon Resonance (SPR)Biolayer Interferometry (BLI)Isothermal Titration Calorimetry (ITC)Brd4BD2VHLPPM1DCereblon (CRBN)KineticsThermodynamicsCooperativityHook Effect

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Jiang, W., Soutter, H. The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS). J. Vis. Exp. (203), e65718, doi:10.3791/65718 (2024).

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