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脳からのアミロイド線維コアの生化学的浄化とプロテオミクス特性評価
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Neuroscience
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JoVE Journal Neuroscience
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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脳からのアミロイド線維コアの生化学的浄化とプロテオミクス特性評価

日本語

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2,791 Views

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09:00 min

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April 28, 2022

DOI:

10.3791/63816-v

DOI:
10.3791/63816-v

•

09:00 min
April 28, 2022

•

10 Views
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1Department of Neurology,Northwestern University Feinberg School of Medicine

Summary

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質量分析ベースのプロテオミクス分析によるこの生化学的精製方法は、アミロイド線維コアの堅牢な特性評価を容易にし、アルツハイマー病を予防するための標的の同定を加速させる可能性がある。

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Cite this Article

Upadhyay, A., Vassar, R. J., Savas, J. N. Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain. J. Vis. Exp. (182), e63816, doi:10.3791/63816 (2022).

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