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来自大脑的淀粉样原纤维核心的生化纯化和蛋白质组学表征
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Neuroscience
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JoVE Journal Neuroscience
Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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来自大脑的淀粉样原纤维核心的生化纯化和蛋白质组学表征

English

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2,774 Views

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09:00 min

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April 28, 2022

DOI:

10.3791/63816-v

DOI:
10.3791/63816-v

•

09:00 min
April 28, 2022

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10 Views
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1Department of Neurology,Northwestern University Feinberg School of Medicine

Summary

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这种基于质谱的蛋白质组学分析的生化纯化方法有助于淀粉样原纤维核心的稳健表征，这可以加速预防阿尔茨海默病的靶标的鉴定。

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Cite this Article

Upadhyay, A., Vassar, R. J., Savas, J. N. Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain. J. Vis. Exp. (182), e63816, doi:10.3791/63816 (2022).

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