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Entrega intraduto e visualização de raios-X da solução ablativa baseada em etanol para prevenção e tratamento local do câncer de mama em modelos de camundongos
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April 01, 2022
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1Precision Health Program,Michigan State University, 2Department of Radiology, College of Human Medicine,Michigan State University, 3Department of Pharmacology & Toxicology, College of Veterinary Medicine,Michigan State University, 4College of Osteopathic Medicine,Michigan State University, 5Advanced Materials Characterization Laboratory/Materials Research Center,Missouri University of Science and Technology, 6Institute for Quantitative (IQ) Health Science and Engineering Advanced Molecular Imaging Facility,Michigan State University, 7Department of Obstetrics Gynecology and Reproductive Biology, College of Human Medicine,Michigan State University, 8Institute for Quantitative (IQ) Health Science and Engineering,Michigan State University, 9Van Andel Research Institute, 10Miltenyi Biotec, 11Veterinary Diagnostic Laboratory, College of Veterinary Medicine,Michigan State University
Summary
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Um método de injeção intradutal de reagentes para uma solução ablativa à base de etanol para a árvore ductal mamária do camundongo para a imagem in vivo e prevenção do câncer de mama é descrito. A injeção diretamente na abertura do mamilo permite atingir células epiteliais mamárias com danos colaterais mínimos.
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Kenyon, E., Zaluzec, E. K., Powell, K., Volk, M., Chakravarty, S., Hix, J., Arora, R., Westerhuis, J. J., Kiupel, M., Shapiro, E. M., Sempere, L. F. Intraductal Delivery and X-ray Visualization of Ethanol-Based Ablative Solution for Prevention and Local Treatment of Breast Cancer in Mouse Models. J. Vis. Exp. (182), e63457, doi:10.3791/63457 (2022).
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